Featured Resources

Harnessing the potential of wearables in clinical trials

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Master Protocols

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Identifying Choice Trial Designs Using Pareto

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Employing the Power of Bayesian Methods to Expedite Learning

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Overcoming Clinical Development Challenges in Oncology with Innovative, Adaptive Trial Design

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Demystifying synthetic control arms

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Biometrics for your modern oncology trials

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Adaptive Trials at the Mainstream of Drug Development

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Use of Real-world evidence expands to transform drug development

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Re-imagining Clinical Trials Whitepaper

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Adaptive Trials for Clinical Trials – NEJM

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Recent Publications

Key Publications
2020
  • Harari O, Hsu G, Dron L, Park JJH, Mills EJ, Thorlund K. Utilizing Bayesian Predictive Power in Clinical Trial Design. Pharmaceutical Statistics. 2020; 1– 16. https://doi.org/10.1002/pst.2073
2019
  • Forrest JI, Rayner CR, Park JJH, Mills EJ. Early Treatment of COVID-19 Disease: A Missed Opportunity. Infectious Diseases and Therapy. 2020; DOI: 10.1007/s40121-020-00349-8
2018
  • Dillman A, Park JJH, Zannat NE, Lee Z, Dron L, Hsu G, Smith G, Khakabimamaghani S, Harari O, Thorlund K, Mills EJ. Reporting and Design of Randomized Clinical Trials for COVID-19: A Systematic Review. Contemporary Clinical Trials. 2021;101:106239
2017
  • Dillman A, Park JJH, Zannat NE, Lee Z, Dron L, Hsu G, Smith G, Khakabimamaghani S, Harari O, Thorlund K, Mills EJ. Reporting and Design of Randomized Clinical Trials for COVID-19: A Systematic Review. Contemporary Clinical Trials. 2021;101:106239
2016
  • Dillman A, Zorratti M, Park JJH, Hsu G, Dron L, Smith G, Harari O, Rayner CR, Zannat NE, Gupta A, Mackay E, Arora P, Lee Z, Mills EJ. The landscape of emerging randomized clinical trial evidence for COVID-19 disease stages: A systematic review of global trial registries. Infection and Drug Resistance. 2020. Accepted
2015
  • Accelerating Clinical Evaluation of Repurposed Combination Therapies for COVID-19 Craig R. Rayner, Louis Dron, Jay J. H. Park, Eric H. Decloedt, Mark F. Cotton, Vis Niranjan, Patrick F. Smith, Michael G. Dodds, Fran Brown, Gilmar Reis, David Wesche, Edward J. Mills
2014
  • Lancet Global Health 4 series on “Series in Clinical Trials in Global Health” – Forthcoming:
2013
  • Park JJH, Grais R, Taljard M, Nakimuli-Mpungu E, Jehan F, Nachega J, Ford N, Xavier D, Kengne A, Ashorn P, Socias ME, Bhutta ZA, Mills EJ. Global health clinical trials: Urgently seeking efficiency and sustainability. Lancet Global Health, 2020. Accepted
PSE RELAVANT PUBLICATIOMS
  • Park JJH, Ford N, Xavier D, Ashorn P, Grais R, Bhutta ZA, Goossens H, Thorlund T, Socias ME, Mills EJ. Global health clinical trials: Randomised trials at the level of individual. Lancet Global Health, 2020. AcceptedDron L, Taljard M, Cheung YB, Grais R, Ford N, Thorlund K, Jahan F, Nakimuli-Mpungu E, Xavier D, Bhutta ZA, Park JJH, Mills EJ. Global health clinical trials: Role and challenges of cluster randomized trials for global health. Lancet Global Health, 2020. Accepted

    Park JJH, Mogg R, Smith GE, Nakimuli-Mpungu E, Jehan F, Rayner CR, Condo J, Decloedt EH, Nachega J, Reis G, Mills EJ. How COVID-19 fundamentally changed clinical research in global health. Lancet Global Health, 2020. Accepted

    Chen, Xianwen MD; Ren, Cuiping MD; Li, Juan MD; Wang, Shangpei MD; Dron, Louis MSc; Harari, Ofir PhD; Whittington, Craig PhD The Efficacy and Safety of Piribedil Relative to Pramipexole for the Treatment of Early Parkinson Disease: A Systematic Literature Review and Network Meta-Analysis, Clinical Neuropharmacology: 7/8 2020 – Volume 43 – Issue 4 – p 100-106 doi: 10.1097/WNF.0000000000000400

    Ghosh P, Liu L, Mehta CR. Adaptive Multiarm Multistage Clinical Trials. Statistics in Medicine, 2020; 39:1084-1102.

    Ferreira JP, Mehta CR, Sharma A, Nissen SE, Rossignol P, Zannad F. Alogliptin after acute coronary syndrome in patients with type 2 diabetes: a renal function stratified analysis of the EXAMINE trial. BMC Medicine, 2020; 18:165.

    Elharram M, Sharma A, White W, Bakris G, Rossignol P, Mehta CR, Ferreira JP, Zannad, F. Timing of Randomization after an Acute Coronary Syndrome in Patients with Type-2 Diabetes Mellitus. American Heart Journal, 2020 (in Press).

    Ferreira JP, Rossignol P, Sharma, A, White WB, Mehta CR, Bakris G, Zannad, F. Multi-proteomic approach to predict specific cardiovascular events in patients with diabetes and myocardial infarction: findings from the EXAMINE trial. Clinical Research in Cardiology, 2020. Published on-line, DOI 10.1007/s00392-020-01729-3.

    Ankolekar S., Mehta C., Mukherjee R., Hsiao S., Smith J., Haddad T. (2020) Monte Carlo Simulation for Trial Design Tool. In: Piantadosi S., Meinert C. (eds) Principles and Practice of Clinical Trials. Springer, Cham. https://doi.org/10.1007/978-3-319-52677-5_251-1